About 130,000 cases of malaria
are reported annually in Brazil.
99% in the Amazon Region.
RECURRENCES
Recurrence of malaria is a frequent event that can contribute to the maintenance of disease transmission. Currently few studies address the different aspects related to this phenomenon.
Recurrent episodes of malaria can arise from three mainsources:
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Reinfections in areas of active transmission;
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Recrudescence due to the lack of anti-schizonticidal efficacy of antimalarials;
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Relapses are the reactivation of P. vivax hypnozoites from the dormant stage of the parasite in the liver.
ABRACAMAL
Abracamal studies aim to help develop evidence-based guidelines for the Brazilian National Malaria Prevention and Control Program (PNCM) by addressing the changes in Brazil's malaria transmission scenario, the high morbidity rates, and the risk of resistance to the currently recommended treatment.
The projects “Elucidating the contribution of vivax malaria recurrence components to radical cure” and “Clinical and molecular epidemiology of Plasmodium falciparum malaria in the basin Brazilian Amazon: implications for the National Program for Malaria Control“ are prospective, multicenter studies that recruit patients in Brazilian areas with varying transmission intensitie. These studies aim to evaluate clinical and parasitological responses to the treatment of uncomplicated infections caused by Plasmodium vivax and P. falciparum.
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PROJECTS
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Project P. vivax
Elucidating the contribution of vivax malaria recurrence components to radical cure
A multicenter prospective study designed to evaluate the clinical and parasitological responses of uncomplicated P. vivax infection treatment, with emphasis on vivax relapses.
The research aims to delineate the various components of relapses, considering multiple facets of the malaria infection process and undertaking a comprehensive assessment of aspects relating to the host, parasite, and drug.
The study's primary objective is to estimate the global incidence density rate of symptomatic recurrent P. vivax parasitemia over a 12-month period, while also examining clinical, biological, and laboratory markers associated with P. vivax relapse.
Project P. falciparum
Clinical and molecular epidemiology of Plasmodium falciparum malaria in the basin Brazilian Amazon: implications for the National Program for Malaria Control
The objective of this study is to investigate the clinical and molecular epidemiology of Plasmodium falciparum infection, including the parasite clearance kinetics, the presence of mutations associated with delayed clearance, the genetic deletion of pfhrp2/3, and its impact on therapeutic and parasitological response.
The primary objective is to estimate the overall rate of therapeutic response and parasitological clearance in P. falciparum infections.
PARTNERS
